I don't use it myself (I use slrn), but Unison (http://www.panic.com/unison/) is GUI and is Universal (i.e. IntelMac-ready) and seems to be pretty decent. It's only real downside is that it's not free.
I don't use any newsreaders, so I can't give any recommendations. However, I'm a fan of the guys at panic.com, so I'd give Unison (suggested above) a try. There's a free trial period.
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